Which medication category is used to suppress the immune response in MG?

• A. Antibiotics
• B. Antihistamines
• C. Diuretics
• D. Immunosuppressants

Answer: (D)

In myasthenia gravis, the immune system creates antibodies that attack the acetylcholine receptors at the neuromuscular junction, causing muscle weakness. To address this autoimmune attack, controlling the immune response is essential. Immunosuppressants are the medication category used because they dampen the immune system’s activity, reducing the production of these harmful antibodies and the ongoing attack on the NMJ. This helps improve muscle strength over time and is often used when symptoms require more than symptomatic relief from acetylcholinesterase inhibitors, or to minimize long-term steroid use.

Think of the other options as treating symptoms or unrelated issues: antibiotics treat infections, antihistamines block allergic reactions, and diuretics influence fluid balance. None of these address the autoimmune process at the heart of MG, which is why they aren’t the appropriate choice for suppressing the immune response in this condition.