What percentage of ALS cases are genetic (often linked with FTD)?

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Multiple Choice

What percentage of ALS cases are genetic (often linked with FTD)?

Explanation:
Genetic contribution to ALS is a minority. About five to ten percent of ALS cases are familial and due to inherited mutations, with the C9orf72 expansion being the major link to frontotemporal dementia, along with other genes like SOD1, TARDBP, and FUS. Because most ALS cases occur without a family history, the overall genetic portion fits the five-to-ten percent range, making that option the best estimate. The other percentages overstate or ignore the well-established fact that most cases are sporadic.

Genetic contribution to ALS is a minority. About five to ten percent of ALS cases are familial and due to inherited mutations, with the C9orf72 expansion being the major link to frontotemporal dementia, along with other genes like SOD1, TARDBP, and FUS. Because most ALS cases occur without a family history, the overall genetic portion fits the five-to-ten percent range, making that option the best estimate. The other percentages overstate or ignore the well-established fact that most cases are sporadic.

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