Oligodendroglioma most commonly arises in which brain lobes?

• A. Frontal and temporal lobes
• B. Parietal and occipital lobes
• C. Brainstem
• D. Cerebellum

Answer: (A)

Oligodendrogliomas originate most often in the cerebral hemispheres, with a strong preference for the frontal lobe and often involving the adjacent temporal lobe. This fronto-temporal localization explains their typical presentation, including seizures and changes in personality or cognition when the frontal area is involved. While they can appear elsewhere, the frontal and temporal regions are the most characteristic sites, whereas involvement of the brainstem or cerebellum is uncommon for this tumor type, and parietal/occipital locations are less typical than fronto-temporal. Therefore, the best answer is frontal and temporal lobes.