In SCAN1, which of the following is a typical feature?

• A. Peripheral neuropathy
• B. Increased reflexes
• C. Cardiac arrhythmias
• D. Visual loss

Answer: (A)

The main idea here is that SCAN1 typically involves the peripheral nerves, producing a peripheral neuropathy. This means patients often experience sensory and motor symptoms in the distal limbs due to damage to the nerves outside the brain and spinal cord, which also tends to give you reduced or absent reflexes.

In contrast, features like increased reflexes point to central or upper motor neuron processes, not peripheral nerve disease, and cardiac arrhythmias or visual loss would suggest involvement of the heart or optic system rather than a primary peripheral neuropathy. So recognizing the pattern of peripheral nerve involvement makes peripheral neuropathy the best fit for SCAN1.