In MG rehabilitation, what is the suggested initial resistance training intensity (as a percentage of 1RM)?

• A. 5-10% 1RM
• B. 30-50% 1RM
• C. 70-90% 1RM
• D. 100% 1RM

Answer: (B)

In MG rehabilitation, the goal is to build strength without triggering excessive fatigue. Myasthenia gravis causes rapid fatigability, so exercising with too much load can worsen weakness after activity and hinder recovery. Starting with a moderate resistance—about 30-50% of the one-repetition maximum—strikes a balance: it provides enough stimulus to recruit and strengthen muscles while keeping effort within a tolerable range for someone with MG. This intensity supports safe progression, allowing small, gradual increases as fatigue and function are monitored.

Lower loads like 5-10% may feel too easy to produce meaningful strength gains initially, while very high intensities such as 70% or more are likely to provoke significant fatigue and symptom flare-ups, especially early in rehabilitation. Thus, 30-50% of 1RM is the best starting point to promote adaptation safely.