Glioblastoma multiforme is most often located in which brain region?

• A. Cerebellum
• B. Spinal cord
• C. Cerebral hemispheres
• D. Brainstem

Answer: (C)

Glioblastoma multiforme most often arises in the cerebral hemispheres, typically in the frontal and temporal lobes. This reflects the pattern seen in adults, where these tumors infiltrate the white matter of the hemispheres and grow quickly, sometimes crossing to the opposite side via the corpus callosum (the classic “butterfly” appearance). While tumors can occur elsewhere, the cerebellum, brainstem, and spinal cord are much less commonly involved by GBM.

So the cerebral hemispheres are the most common site because adult GBMs preferentially develop there, with frequent involvement of the frontal/temporal white matter.