GBS medical treatment includes which of the following?

• A. Interferon therapy
• B. Antibiotics
• C. Steroid monotherapy
• D. IVIG and plasmapheresis

Answer: (D)

Guillain-Barré Syndrome is an immune-mediated attack on the peripheral nerves, so treatment aims to modulate or remove the immune factors and support recovery. The two established disease-modifying therapies are intravenous immunoglobulin (IVIG) and plasma exchange (plasmapheresis). IVIG works by modulating the immune response and dampening the attack on nerve components, often shortening recovery. Plasma exchange removes circulating autoantibodies and inflammatory mediators, which can also hasten improvement. Either approach is considered in moderate to severe cases and is most beneficial when started early.

Antibiotics address infections, not the autoimmune process driving GBS, so they’re not a treatment for the neuropathy unless an infection is present. Interferon therapy is not a standard treatment for GBS, as it hasn’t shown a clear benefit. Steroid monotherapy has not demonstrated meaningful improvement in GBS outcomes and is not used as the primary treatment.