Dissemination in space, a McDonald criteria concept, is defined as:

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Multiple Choice

Dissemination in space, a McDonald criteria concept, is defined as:

Explanation:
Dissemination in space means MS lesions appear in more than one distinct area of the CNS. In the McDonald criteria this is demonstrated when MRI shows lesions in at least two different CNS regions, such as periventricular, juxtacortical, infratentorial, or spinal cord. If all lesions are confined to a single region, it does not satisfy dissemination in space. This concept is paired with dissemination in time (new lesions appearing over time) to support a diagnosis of MS.

Dissemination in space means MS lesions appear in more than one distinct area of the CNS. In the McDonald criteria this is demonstrated when MRI shows lesions in at least two different CNS regions, such as periventricular, juxtacortical, infratentorial, or spinal cord. If all lesions are confined to a single region, it does not satisfy dissemination in space. This concept is paired with dissemination in time (new lesions appearing over time) to support a diagnosis of MS.

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