Bevacizumab commonly causes which adverse effects?

• A. Hypertension
• B. Hypotension
• C. Hyperglycemia
• D. Hyperkalemia

Answer: (A)

VEGF inhibition with bevacizumab commonly raises blood pressure. VEGF helps vessels release nitric oxide, a natural vasodilator. When VEGF signaling is blocked, less nitric oxide is produced, vessels constrict more, and systemic vascular resistance goes up, leading to hypertension. This is one of the most frequent and clinically important adverse effects you’ll monitor for during therapy, so regular blood pressure checks and appropriate antihypertensive management are essential.

The other options aren’t typical for bevacizumab: hypotension isn’t a common pattern with VEGF inhibitors, and hyperglycemia or hyperkalemia are not characteristic adverse effects of this drug class.