AMAN has which characteristic among its features?

• A. Selective attack on motor axons
• B. Affects sensory fibers predominantly
• C. Is a central nervous system demyelinating disorder
• D. Is identical to AIDP

Answer: (D)

AMAN (Acute Motor Axonal Neuropathy) is a Guillain-Barré syndrome variant where the immune attack targets motor nerve axons rather than the myelin sheath. This leads to rapidly progressive motor weakness with little or no sensory loss. Nerve conduction studies typically show that motor responses are reduced or absent while sensory conduction remains relatively preserved, reflecting motor-axon damage.

It's a peripheral nervous system issue, not a central nervous system demyelinating disorder. It is not the same entity as AIDP (the classic demyelinating form of Guillain-Barré syndrome), which involves demyelination rather than primary axonal damage. Therefore, the hallmark feature of AMAN is selective motor axonal involvement, not an identity with AIDP.